MolNFT v1 · #22144 · protein

Core-streptavidin mutant W79F at pH 4.5

1SWJ: “Core-streptavidin mutant W79F at pH 4.5”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #22144 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1SWJ
Type: protein
Length: 460 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Core-streptavidin
UniProt: P22629
Pockets: 4 · best druggability 0.69

Structure

x-ray diffraction · 4 distinct chains · 5% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Core-streptavidin	protein	112	5% helix, 58% strand	P22629
B	Core-streptavidin	protein	118	5% helix, 57% strand	P22629
C	Core-streptavidin	protein	117	5% helix, 57% strand	P22629
D	Core-streptavidin	protein	113	3% helix, 58% strand	P22629

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	322	0.69	0.83	42	empty
2	303	0.63	0.80	42	empty
3	288	0.63	0.80	38	empty
4	278	0.61	0.79	38	empty

Interfaces

6 interfaces between chains.

A–B · 1617 Å² buried · 24 hydrogen bonds · protein-protein
C–D · 1587 Å² buried · 26 hydrogen bonds · protein-protein
B–C · 447 Å² buried · 2 hydrogen bonds · protein-protein
A–D · 405 Å² buried · 2 hydrogen bonds · protein-protein
A–C · 199 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

1SWJ · Core-streptavidin mutant W79F at pH 4.5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22629
Elsewhere: RCSB PDB 1SWJ · PDBe 1SWJ · UniProt P22629

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.