MolNFT v1 · #22007 · protein

Crystal structural analysis of active site mutant Q189E of lgtc

1SS9 · Alpha-1,4-galactosyl transferase: “Crystal structural analysis of active site mutant Q189E of lgtc”. X-ray diffraction, 2 ligands (UPF, MN), 2 pockets (best druggability 0.73). MolNFT v1 #22007 on GenesisL1: 3D structure, binding…

PDB: 1SS9
Type: protein
Length: 280 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-1,4-galactosyl transferase
EC: 2.4.1.44
UniProt: Q93EK7
Ligands: UPF, MN
Pockets: 2 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-1,4-galactosyl transferase (EC 2.4.1.44)	protein	280	38% helix, 16% strand	Q93EK7

Ligands and binding sites

UPF · Uridine-5'-diphosphate-2-deoxy-2-fluorogalactose · ligand · chains A
MN · Manganese (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	262	0.73	0.87	36	UPF
2	54	0.31	0.76	14	empty

Compared structures

1SS9 · Crystal Structural Analysis of Active Site Mutant Q189E of LgtC · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93EK7
Elsewhere: RCSB PDB 1SS9 · PDBe 1SS9 · UniProt Q93EK7

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