MolNFT v1 · #21894 · protein

Aquaporin-0 membrane junctions reveal the structure of a closed water pore

1SOR: “Aquaporin-0 membrane junctions reveal the structure of a closed water pore”. Electron crystallography, 2 pockets (best druggability 0.45). MolNFT v1 #21894 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1SOR
Type: protein
Length: 235 residues
Chains: 1
Method: electron crystallography
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aquaporin-0
UniProt: Q6J8I9
Pockets: 2 · best druggability 0.45

Structure

electron crystallography · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aquaporin-0	protein	235	70% helix, 0% strand	Q6J8I9

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	105	0.45	0.79	23	empty
2	142	0.42	0.75	30	empty

Compared structures

1SOR · Aquaporin-0 membrane junctions reveal the structure of a closed water pore · the same entry in another collection · chain A against A, TM-score 1.00
Q6J8I9 · AlphaFold monomer V2.0 prediction for lens fiber major intrinsic protein (Q6J8I9) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6J8I9
Elsewhere: RCSB PDB 1SOR · PDBe 1SOR · UniProt Q6J8I9

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