MolNFT v1 · #21878 · protein
Abeta-bound human abad structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (type II hadh), endoplasmic reticulum- associated amyloid beta-peptide binding protein (erab)]
1SO8: “Abeta-bound human abad structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II (type II hadh)…”. X-ray diffraction, 2 ligands (NA, CL), 2 pockets (best druggability 0.40). MolNFT v1 #21878 on GenesisL1: 3D structure…
- PDB
- 1SO8
- Type
- protein
- Length
- 208 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-hydroxyacyl-CoA dehydrogenase type II
- EC
- 1.1.1.35
- UniProt
- Q99714
- Ligands
- NA, CL
- Pockets
- 2 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-hydroxyacyl-CoA dehydrogenase type II (EC 1.1.1.35) | protein | 208 | 41% helix, 18% strand | Q99714 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 125 | 0.40 | 0.75 | 22 | empty |
| 2 | 76 | 0.38 | 0.78 | 18 | empty |
Compared structures
- 1SO8 · Abeta-bound human ABAD structure [also known as 3-hydroxyacyl-CoA dehydrogenase type II… · the same entry in another collection · chain A against A, TM-score 1.00
- Q99714 · AlphaFold monomer V2.0 prediction for 3-hydroxyacyl-CoA dehydrogenase type-2 (Q99714) · a predicted model of the same protein · chain A against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99714
- Elsewhere: RCSB PDB 1SO8 · PDBe 1SO8 · UniProt Q99714
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