MolNFT v1 · #21690 · protein

Crystal structure of a SIGMA70 subunit fragment from escherichia COLI RNA polymerase

1SIG · RNA polymerase primary sigma factor: “Crystal structure of a SIGMA70 subunit fragment from escherichia COLI RNA polymerase”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #21690 on GenesisL1: 3D structure, binding…

PDB: 1SIG
Type: protein
Length: 305 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA polymerase primary sigma factor
UniProt: P00579
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 71% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA polymerase primary sigma factor	protein	305	71% helix, 2% strand	P00579

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	175	0.50	0.77	24	empty
2	103	0.48	0.80	25	empty
3	88	0.43	0.79	19	empty
4	72	0.33	0.75	15	empty

Compared structures

1SIG · Crystal structure of a SIGMA70 subunit fragment from escherichia COLI RNA polymerase · the same entry in another collection · chain A against A, TM-score 1.00
P00579 · AlphaFold monomer V2.0 prediction for RNA polymerase sigma factor rpod (P00579) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00579
Elsewhere: RCSB PDB 1SIG · PDBe 1SIG · UniProt P00579

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