MolNFT v1 · #21681 · protein

Protease-like domain from 2-chain hepatocyte growth factor

1SI5: “Protease-like domain from 2-chain hepatocyte growth factor”. X-ray diffraction, 2 pockets (best druggability 0.67). MolNFT v1 #21681 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1SI5
Type: protein
Length: 227 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hepatocyte growth factor
UniProt: P14210
Pockets: 2 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	Hepatocyte growth factor	protein	227	9% helix, 37% strand	P14210

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.67	0.95	28	empty
2	54	0.31	0.76	14	empty

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1SI5 · Protease-like domain from 2-chain hepatocyte growth factor · the same entry in another collection · chain H against H, TM-score 1.00
P14210 · AlphaFold monomer V2.0 prediction for hepatocyte growth factor (P14210) · a predicted model of the same protein · chain H against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14210
Elsewhere: RCSB PDB 1SI5 · PDBe 1SI5 · UniProt P14210

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