MolNFT v1 · #21643 · protein

Crystal structure of norwalk virus polymerase (metal-free, centered orthorhombic)

1SH2 · RNA polymerase: “Crystal structure of norwalk virus polymerase (metal-free, centered orthorhombic)”. X-ray diffraction, 3 pockets (best druggability 0.72). MolNFT v1 #21643 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1SH2
Type: protein
Length: 502 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA polymerase
EC: 2.7.7.48
UniProt: Q70ET3
Pockets: 3 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA polymerase (EC 2.7.7.48)	protein	502	42% helix, 17% strand	Q70ET3

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	752	0.72	0.78	69	empty
2	315	0.60	0.78	48	empty
3	63	0.30	0.75	18	empty

Compared structures

1SH2 · Crystal Structure of Norwalk Virus Polymerase (Metal-free, Centered Orthorhombic) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q70ET3
Elsewhere: RCSB PDB 1SH2 · PDBe 1SH2 · UniProt Q70ET3

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