MolNFT v1 · #21573 · protein
Mature and translocatable forms of glyoxysomal malate dehydrogenase have different activities and stabilities but similar crystal structures
1SEV · Malate dehydrogenase, glyoxysomal precursor: “Mature and translocatable forms of glyoxysomal malate dehydrogenase have different activities and stabilities…”. X-ray diffraction, 6 pockets (best druggability 0.74). MolNFT v1 #21573…
- PDB
- 1SEV
- Type
- protein
- Length
- 626 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Malate dehydrogenase, glyoxysomal precursor
- EC
- 1.1.1.37
- UniProt
- P19446
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Malate dehydrogenase, glyoxysomal precursor (EC 1.1.1.37) | protein | 313 | 46% helix, 19% strand | P19446 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.74 | 0.82 | 60 | empty |
| 2 | 426 | 0.73 | 0.83 | 57 | empty |
| 3 | 240 | 0.49 | 0.74 | 26 | empty |
| 4 | 92 | 0.40 | 0.77 | 15 | empty |
| 5 | 82 | 0.37 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1640 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 1SEV · Mature and translocatable forms of glyoxysomal malate dehydrogenase have different… · the same entry in another collection · chain A against A, TM-score 1.00
- P19446 · AlphaFold monomer V2.0 prediction for malate dehydrogenase, glyoxysomal (P19446) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19446
- Elsewhere: RCSB PDB 1SEV · PDBe 1SEV · UniProt P19446
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