Research workbench
Mature and translocatable forms of glyoxysomal malate dehydrogenase have different activities and stabilities but similar crystal structures
Analyse Mature and translocatable forms of glyoxysomal malate dehydrogenase have… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SEV
- Type
- protein
- Length
- 626 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Malate dehydrogenase, glyoxysomal precursor
- EC
- 1.1.1.37
- UniProt
- P19446
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Malate dehydrogenase, glyoxysomal precursor (EC 1.1.1.37) | protein | 313 | 46% helix, 19% strand | P19446 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 521 | 0.74 | 0.82 | 60 | empty |
| 2 | 426 | 0.73 | 0.83 | 57 | empty |
| 3 | 240 | 0.49 | 0.74 | 26 | empty |
| 4 | 92 | 0.40 | 0.77 | 15 | empty |
| 5 | 82 | 0.37 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1640 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 1SEV · Mature and translocatable forms of glyoxysomal malate dehydrogenase have different… · the same entry in another collection · chain A against A, TM-score 1.00
- P19446 · AlphaFold monomer V2.0 prediction for malate dehydrogenase, glyoxysomal (P19446) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19446
- Elsewhere: RCSB PDB 1SEV · PDBe 1SEV · UniProt P19446
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