MolNFT v1 · #21563 · protein

The structure of active serpin K from manduca sexta and a model for serpin-protease complex formation

1SEK: “The structure of active serpin K from manduca sexta and a model for serpin-protease complex formation”. X-ray diffraction, 2 pockets (best druggability 0.65). MolNFT v1 #21563 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1SEK
Type: protein
Length: 376 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Serpin K
UniProt: P14754
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Serpin K	protein	376	33% helix, 33% strand	P14754

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	288	0.65	0.82	35	empty
2	136	0.59	0.84	31	empty

Compared structures

1SEK · The structure of active serpin K from manduca sexta and a model for serpin-protease… · the same entry in another collection · chain A against A, TM-score 1.00
P14754 · AlphaFold monomer V2.0 prediction for alaserpin (P14754) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14754
Elsewhere: RCSB PDB 1SEK · PDBe 1SEK · UniProt P14754

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