MolNFT v1 · #21523 · protein

Crystal structure of a semet derivative of meci at 2.65 a

1SD7 · Methicillin resistance regulatory protein meci: “Crystal structure of a semet derivative of meci at 2.65 a”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #21523 on GenesisL1: 3D structure, binding sites and…

PDB: 1SD7
Type: protein
Length: 237 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methicillin resistance regulatory protein meci
UniProt: P68262
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 60% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methicillin resistance regulatory protein meci	protein	119	61% helix, 8% strand	P68262
B	Methicillin resistance regulatory protein meci	protein	118	60% helix, 12% strand	P68262

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	92	0.38	0.76	17	empty
2	72	0.33	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 2162 Å² buried · 26 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

1SD7 · Crystal Structure of a SeMet derivative of MecI at 2.65 A · the same entry in another collection · chain A against A, TM-score 1.00
P68262 · AlphaFold monomer V2.0 prediction for methicillin resistance regulatory protein meci… · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P68262
Elsewhere: RCSB PDB 1SD7 · PDBe 1SD7 · UniProt P68262

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