Research workbench
Crystal structure of a semet derivative of meci at 2.65 a
Analyse Crystal structure of a semet derivative of meci at 2.65 a in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1SD7
- Type
- protein
- Length
- 237 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methicillin resistance regulatory protein meci
- UniProt
- P68262
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methicillin resistance regulatory protein meci | protein | 119 | 61% helix, 8% strand | P68262 |
| B | Methicillin resistance regulatory protein meci | protein | 118 | 60% helix, 12% strand | P68262 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 92 | 0.38 | 0.76 | 17 | empty |
| 2 | 72 | 0.33 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 2162 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 1SD7 · Crystal Structure of a SeMet derivative of MecI at 2.65 A · the same entry in another collection · chain A against A, TM-score 1.00
- P68262 · AlphaFold monomer V2.0 prediction for methicillin resistance regulatory protein meci… · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68262
- Elsewhere: RCSB PDB 1SD7 · PDBe 1SD7 · UniProt P68262
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