MolNFT v1 · #21399 · protein
Human soluble epoxide hydrolase
1S8O · Epoxide hydrolase 2, cytoplasmic: “Human soluble epoxide hydrolase”. X-ray diffraction, 5 pockets (best druggability 0.85). MolNFT v1 #21399 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1S8O
- Type
- protein
- Length
- 545 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epoxide hydrolase 2, cytoplasmic
- EC
- 3.3.2.3
- UniProt
- P34913
- Pockets
- 5 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epoxide hydrolase 2, cytoplasmic (EC 3.3.2.3) | protein | 545 | 47% helix, 14% strand | P34913 |
Ligands and binding sites
- P6G · Hexaethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 703 | 0.85 | 0.89 | 56 | empty |
| 2 | 244 | 0.66 | 0.83 | 32 | empty |
| 3 | 450 | 0.59 | 0.74 | 38 | empty |
| 4 | 50 | 0.33 | 0.78 | 13 | empty |
| 5 | 52 | 0.25 | 0.73 | 18 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P34913
- Elsewhere: RCSB PDB 1S8O · PDBe 1S8O · UniProt P34913
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