UniProt P34913
Bifunctional epoxide hydrolase 2 (P34913)
Bifunctional epoxide hydrolase 2 (UniProt P34913), EC 3.1.3.76, 3.3.2.10: 211 experimental structures and 1 predicted model on GenesisL1, 25 ligands bound, 56 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P34913
- Protein
- Bifunctional epoxide hydrolase 2
- EC
- 3.1.3.76, 3.3.2.10
- Experimental structures
- 211
- Predicted models
- 1
- Ligands
- 25
- Pockets
- 56 · 14 records with a druggable one
Structures
212 records of P34913 in the MolNFT archive: 211 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1S8O | Human soluble Epoxide Hydrolase | x-ray diffraction | A | — | — |
| 1S8O | Human soluble epoxide hydrolase | x-ray diffraction | A | — | — |
| 1VJ5 | Human soluble Epoxide Hydrolase- N-cyclohexyl-N'-(4-iodophenyl)urea complex | x-ray diffraction | A | — | — |
| 1VJ5 | Human soluble epoxide hydrolase- N-cyclohexyl-N'-(4-IODOPHENYL)UREA complex | x-ray diffraction | A | — | — |
| 1ZD2 | Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-ethanoic acid complex | x-ray diffraction | P | — | — |
| 1ZD2 | Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)- ethanoic acid complex | x-ray diffraction | P | — | — |
| 1ZD3 | Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-butyric acid complex | x-ray diffraction | A | — | — |
| 1ZD3 | Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)- butyric acid complex | x-ray diffraction | A | — | — |
| 1ZD4 | Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex | x-ray diffraction | A | — | — |
| 1ZD4 | Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex | x-ray diffraction | A | — | — |
| 1ZD5 | Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-heptanoic acid complex | x-ray diffraction | A | — | — |
| 1ZD5 | Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)- heptanoic acid complex | x-ray diffraction | A | — | — |
| 3ANS | Human soluble epoxide hydrolase in complex with a synthetic inhibitor | x-ray diffraction | A, B | — | — |
| 3ANS | Human soluble epoxide hydrolase in complex with a synthetic inhibitor | x-ray diffraction | A, B | — | — |
| 3ANT | Human soluble epoxide hydrolase in complex with a synthetic inhibitor | x-ray diffraction | A, B | — | — |
| 3ANT | Human soluble epoxide hydrolase in complex with a synthetic inhibitor | x-ray diffraction | A, B | — | — |
| 3I1Y | Crystal Structure of soluble epoxide Hydrolase | x-ray diffraction | A | — | — |
| 3I1Y | Crystal structure of soluble epoxide hydrolase | x-ray diffraction | A | — | — |
| 3I28 | Crystal Structure of soluble epoxide Hydrolase | x-ray diffraction | A | — | — |
| 3I28 | Crystal structure of soluble epoxide hydrolase | x-ray diffraction | A | — | — |
| 3KOO | Crystal Structure of soluble epoxide Hydrolase | x-ray diffraction | A | — | — |
| 3KOO | Crystal structure of soluble epoxide hydrolase | x-ray diffraction | A | — | — |
| 3OTQ | Soluble Epoxide Hydrolase in complex with pyrazole antagonist | x-ray diffraction | A | — | — |
| 3OTQ | Soluble epoxide hydrolase in complex with pyrazole antagonist | x-ray diffraction | A | — | — |
| 3PDC | Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a… | x-ray diffraction | A, B | — | — |
| 3PDC | Crystal structure of hydrolase domain of human soluble epoxide hydrolase complexed with a… | x-ray diffraction | A, B | — | — |
| 3WK4 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK4 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK5 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK5 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK6 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK6 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK7 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK7 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK8 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK8 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK9 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WK9 | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKA | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKA | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKB | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKB | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKC | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKC | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKD | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKD | Crystal structure of soluble epoxide hydrolase in complex with fragment inhibitor | x-ray diffraction | A | — | — |
| 3WKE | Crystal structure of soluble epoxide hydrolase in complex with t-AUCB | x-ray diffraction | A | — | — |
| 3WKE | Crystal structure of soluble epoxide hydrolase in complex with T-aucb | x-ray diffraction | A | — | — |
| 4C4X | Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with C9 | x-ray diffraction | A, B | — | — |
| 4C4X | Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with C9 | x-ray diffraction | A, B | — | — |
| 4C4Y | Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with A4 | x-ray diffraction | A | — | — |
| 4C4Y | Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with A4 | x-ray diffraction | A | — | — |
| 4C4Z | Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with A8 | x-ray diffraction | A, B | — | — |
| 4C4Z | Crystal structure of human bifunctional epoxide hydroxylase 2 complexed with A8 | x-ray diffraction | A, B | — | — |
| 4HAI | Crystal structure of human soluble epoxide hydrolase complexed with… | x-ray diffraction | A | — | — |
| 4HAI | Crystal structure of human soluble epoxide hydrolase complexed with N… | x-ray diffraction | A | — | — |
| 4J03 | Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant | x-ray diffraction | A | — | — |
| 4J03 | Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant | x-ray diffraction | A | — | — |
| 4JNC | Soluble Epoxide Hydrolase complexed with a carboxamide inhibitor | x-ray diffraction | A | — | — |
| 4JNC | Soluble epoxide hydrolase complexed with a carboxamide inhibitor | x-ray diffraction | A | — | — |
152 records more on the page itself.
Ligands
- MG · Magnesium ion · in 12 records
- 5IV · ~{N}-[[4-(cyclopropylsulfonylamino)-2-(trifluoromethyl)phenyl]methyl]-1-[(3-fluorophenyl) methyl]indole-5-carboxamide · in 2 records
- 8S9 · 3-[4-(3,4-dichlorophenyl)-5-phenyl-1,3-oxazol-2-yl]benzoic acid · in 2 records
- BXV · 4-{[trans-4-({[4-(trifluoromethoxy) phenyl]carbamoyl}amino)cyclohexyl]oxy}benzoic acid · in 2 records
- CL · Chloride ion · in 2 records
- G3T · 1-[4-[[(2~{S})-4-~{tert}-butylmorpholin-2-yl]methoxy]phenyl]-3-cyclohexyl-urea · in 2 records
- PO4 · Phosphate ion · in 2 records
- PTG · (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- TK9 · (2~{R})-2-[[4-[[4-methoxy-2-(trifluoromethyl) phenyl]methylcarbamoyl]phenyl]methyl]butanoic acid · in 2 records
- 3C5 · N-methyl-1-[3-(pyridin-3-yl)phenyl]methanamine · in 1 record
- 49G · N-[(1-methyl-1H-pyrazol-3-yl)methyl]-2-phenylethanamine · in 1 record
- 49N · 1-[3-(trifluoromethyl)pyridin-2-yl]piperazine · in 1 record
- 49O · 2-(piperazin-1-yl)pyridine-3-carbonitrile · in 1 record
- 4VY · 2-[(5-bromo-2-pyridyl)-methyl-amino]ethanol · in 1 record
- 6N0 · N-(5,5-dioxodibenzothiophen-2-yl)-4,4-difluoro-piperidine-1-carboxamide · in 1 record
- 6N4 · 2-(1H-benzimidazol-2-ylsulfanyl)ethanol · in 1 record
- E3N · 1-[(4~{S})-9-propan-2-ylsulfonyl-1-oxa-9-azaspiro[5.5]undecan-4-yl]-3-[[4-(trifluoromethyloxy) phenyl]methyl]urea · in 1 record
- G3Q · R-talinolol · in 1 record
- G3W · 2-(4-fluorophenyl)-~{N}-[(4-phenoxyphenyl) methyl]ethanamine · in 1 record
- J0U · (2S)-2-[2,4-bis(oxidanyl)phenyl]-5-methoxy-8-[(2R)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]-7-oxidanyl-2,3-dihydrochromen-4-one · in 1 record
- K2T · 6-methyl-1,3-benzothiazol-2-amine · in 1 record
- OWW · 3-[(3~{R})-3-[aminocarbonyl(oxidanyl)amino]but-1-ynyl]-~{N}-[(3~{S})-3-phenyl-3-[4-(trifluoromethyloxy) phenyl]propyl]benzamide · in 1 record
- SZC · N-cyclopentyl-2-[4-(trifluoromethyl)phenyl]-3H-benzimidazole-4-sulfonamide · in 1 record
- W6O · (3~{a}~{R},6~{a}~{S})-~{N}-[(2,4-dichlorophenyl)methyl]-2-(4-methylphenyl)sulfonyl-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-5-carboxamide · in 1 record
Experiment against prediction
- 6HGX chain A against the predicted model P34913: TM-score 1.00, RMSD 0.30 Å
- 4X6X chain A against the predicted model P34913: TM-score 1.00, RMSD 0.30 Å
- 7A7G chain B against the predicted model P34913: TM-score 1.00, RMSD 0.35 Å
- 7A7G chain A against the predicted model P34913: TM-score 1.00, RMSD 0.35 Å
- 4C4Z chain A against the predicted model P34913: TM-score 1.00, RMSD 0.37 Å
- 7P4K chain A against the predicted model P34913: TM-score 1.00, RMSD 0.37 Å
- 7P4K chain A against the predicted model P34913: TM-score 1.00, RMSD 0.37 Å
- 7P4K chain B against the predicted model P34913: TM-score 1.00, RMSD 0.40 Å
- 7P4K chain B against the predicted model P34913: TM-score 1.00, RMSD 0.40 Å
- 4JNC chain A against the predicted model P34913: TM-score 1.00, RMSD 0.42 Å
Elsewhere
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