MolNFT v1 · #21366 · protein
Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with coenzyme a (CoA free sulfhydryl)
1S7N · Acetyl transferase: “Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with coenzyme a (CoA free sulfhydryl)”. X-ray diffraction, 1 ligand (COA), 5 pockets (best druggability 0.78). MolNFT v1 #21366 on GenesisL1: 3D…
- PDB
- 1S7N
- Type
- protein
- Length
- 709 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acetyl transferase
- EC
- 2.3.1.-
- UniProt
- Q8ZPC0
- Ligands
- COA
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 38% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acetyl transferase (EC 2.3.1.-) | protein | 177 | 38% helix, 37% strand | Q8ZPC0 |
| B | Acetyl transferase (EC 2.3.1.-) | protein | 179 | 37% helix, 36% strand | Q8ZPC0 |
| C | Acetyl transferase (EC 2.3.1.-) | protein | 176 | 39% helix, 37% strand | Q8ZPC0 |
| D | Acetyl transferase (EC 2.3.1.-) | protein | 177 | 40% helix, 37% strand | Q8ZPC0 |
Ligands and binding sites
- COA · Coenzyme A · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 851 | 0.78 | 0.81 | 76 | COA |
| 2 | 802 | 0.78 | 0.81 | 62 | COA |
| 3 | 815 | 0.77 | 0.80 | 68 | COA |
| 4 | 746 | 0.76 | 0.80 | 61 | COA |
| 5 | 138 | 0.48 | 0.78 | 25 | empty |
Interfaces
3 interfaces between chains.
- A–B · 959 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 954 Ų buried · 13 hydrogen bonds · protein-protein
- A–C · 313 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1S7N · Ribosomal L7/L12 alpha-N-protein acetyltransferase in complex with Coenzyme A (CoA free… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ZPC0
- Elsewhere: RCSB PDB 1S7N · PDBe 1S7N · UniProt Q8ZPC0
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