MolNFT v1 · #21326 · protein
Crystal structure of the complex between KCHIP1 and KV4.2 N1-30
1S6C · KV4 potassium channel-interacting protein KCHIP1B: “Crystal structure of the complex between KCHIP1 and KV4.2 N1-30”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.70). MolNFT v1 #21326 on GenesisL1: 3D structure…
- PDB
- 1S6C
- Type
- protein
- Length
- 188 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- KV4 potassium channel-interacting protein KCHIP1B; Potassium voltage-gated channel…
- UniProt
- Q8R426, Q63881
- Ligands
- CA
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | KV4 potassium channel-interacting protein KCHIP1B | protein | 167 | 66% helix, 5% strand | Q8R426 |
| B | Potassium voltage-gated channel subfamily D member 2 | protein | 21 | 67% helix, 0% strand | Q63881 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.70 | 0.90 | 19 | empty |
| 2 | 141 | 0.59 | 0.83 | 29 | empty |
| 3 | 65 | 0.31 | 0.75 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 892 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (artifact).
Compared structures
- 1S6C · Crystal structure of the complex between KChIP1 and Kv4.2 N1-30 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8R426 · AlphaFold monomer V2.0 prediction for kv channel-interacting protein 1 (Q8R426) · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q63881 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily D member… · a predicted model of the same protein · chain B against A, TM-score 0.49
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R426
- Every structure of UniProt Q63881
- Elsewhere: RCSB PDB 1S6C · PDBe 1S6C · UniProt Q8R426 · UniProt Q63881
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