MolNFT v1 · #21279 · protein

X-ray structure of the GLUR6 ligand binding core (S1S2A) in complex with glutamate at 1.65 a resolution

1S50 · Glutamate receptor 6: “X-ray structure of the GLUR6 ligand binding core (S1S2A) in complex with glutamate at 1.65 a resolution”. X-ray diffraction, 1 ligand (GLU), 2 pockets (best druggability 0.43). MolNFT v1 #21279 on GenesisL1…

PDB: 1S50
Type: protein
Length: 258 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glutamate receptor 6
UniProt: P42260
Ligands: GLU
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glutamate receptor 6	protein	258	38% helix, 21% strand	P42260

Ligands and binding sites

GLU · Glutamic acid · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	133	0.43	0.76	31	empty
2	53	0.28	0.74	16	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1S50 · X-ray structure of the GluR6 ligand binding core (S1S2A) in complex with glutamate at… · the same entry in another collection · chain A against A, TM-score 1.00
P42260 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 2 (P42260) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42260
Elsewhere: RCSB PDB 1S50 · PDBe 1S50 · UniProt P42260

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