MolNFT v1 · #21253 · protein

Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from bovine viral diarrhea virus complexed with GTP

1S49: “Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from bovine viral diarrhea…”. X-ray diffraction, 1 ligand (GTP), 9 pockets (best druggability 0.68). MolNFT v1 #21253 on GenesisL1: 3D structure…

PDB: 1S49
Type: protein
Length: 588 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA-dependent RNA polymerase
UniProt: P19711
Ligands: GTP
Pockets: 9 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA-dependent RNA polymerase	protein	588	43% helix, 15% strand	P19711

Ligands and binding sites

GTP · Guanosine-5'-triphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	288	0.68	0.83	32	empty
2	261	0.64	0.81	27	GTP
3	151	0.57	0.82	24	empty
4	189	0.56	0.80	32	empty
5	141	0.53	0.81	33	empty

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

1S49 · Crystal Structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19711
Elsewhere: RCSB PDB 1S49 · PDBe 1S49 · UniProt P19711

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