MolNFT v1 · #21244 · protein
The crystal structure of the human HSP70 ATPase domain
1S3X · Heat shock 70 kda protein 1: “The crystal structure of the human HSP70 ATPase domain”. X-ray diffraction, 4 ligands (ADP, CA, NA), 1 pocket (best druggability 0.79). MolNFT v1 #21244 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1S3X
- Type
- protein
- Length
- 380 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1
- UniProt
- P08107
- Ligands
- ADP, CA, NA, PO4
- Pockets
- 1 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1 | protein | 380 | 40% helix, 28% strand | P08107 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- CA · Calcium ion · metal · 2 copies · chains A
- NA · Sodium ion · metal · 2 copies · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 759 | 0.79 | 0.83 | 75 | PO4, CA, NA, ADP |
Compared structures
- 1S3X · The crystal structure of the human Hsp70 ATPase domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08107
- Elsewhere: RCSB PDB 1S3X · PDBe 1S3X · UniProt P08107
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