MolNFT v1 · #20894 · protein
C-terminal domain (haemopexin-like domain) of human matrix metalloproteinase-2
1RTG · Human gelatinase a: “C-terminal domain (haemopexin-like domain) of human matrix metalloproteinase-2”. X-ray diffraction, 2 ligands (CA, CL), 2 pockets (best druggability 0.57). MolNFT v1 #20894 on GenesisL1: 3D structure, binding…
- PDB
- 1RTG
- Type
- protein
- Length
- 203 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Human gelatinase a
- EC
- 3.4.24.24
- UniProt
- P08253
- Ligands
- CA, CL
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 8% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Human gelatinase a (EC 3.4.24.24) | protein | 203 | 8% helix, 41% strand | P08253 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 101 | 0.57 | 0.86 | 20 | empty |
| 2 | 105 | 0.44 | 0.78 | 15 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1RTG · C-terminal domain (haemopexin-like domain) of human matrix metalloproteinase-2 · the same entry in another collection · chain A against A, TM-score 1.00
- P08253 · AlphaFold monomer V2.0 prediction for 72 kda type IV collagenase (P08253) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08253
- Elsewhere: RCSB PDB 1RTG · PDBe 1RTG · UniProt P08253
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