MolNFT v1 · #20648 · protein

Crystal structure of the complex of resistant strain of HIV-1 PROTEASE(V82A mutant) with ritonavir

1RL8 · Protease retropepsin: “Crystal structure of the complex of resistant strain of HIV-1 PROTEASE(V82A mutant) with ritonavir”. X-ray diffraction, 1 ligand (RIT), 1 pocket (best druggability 0.68). MolNFT v1 #20648 on GenesisL1: 3D…

PDB: 1RL8
Type: protein
Length: 198 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protease retropepsin
EC: 3.4.23.16
UniProt: P03367
Ligands: RIT
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 6% helix, 57% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protease retropepsin (EC 3.4.23.16)	protein	99	6% helix, 57% strand	P03367

Ligands and binding sites

RIT · Ritonavir · ligand · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	404	0.68	0.80	36	RIT

Interfaces

1 interface between chains.

A–B · 1844 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

1RL8 · Crystal structure of the complex of resistant strain of hiv-1 protease(v82a mutant) with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03367
Elsewhere: RCSB PDB 1RL8 · PDBe 1RL8 · UniProt P03367

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