MolNFT v1 · #20605 · protein

Human plasminogen catalytic domain, K698M mutant

1RJX: “Human plasminogen catalytic domain, K698M mutant”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.35). MolNFT v1 #20605 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1RJX
Type: protein
Length: 243 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Plasminogen
EC: 3.4.21.7
UniProt: P00747
Ligands: SO4
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 10% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Plasminogen (EC 3.4.21.7)	protein	243	10% helix, 35% strand	P00747

Ligands and binding sites

SO4 · Sulfate ion · ion · 8 copies · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	65	0.35	0.77	20	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1RJX · Human PLASMINOGEN CATALYTIC DOMAIN, K698M MUTANT · the same entry in another collection · chain B against B, TM-score 1.00
P00747 · AlphaFold monomer V2.0 prediction for plasminogen (P00747) · a predicted model of the same protein · chain B against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00747
Elsewhere: RCSB PDB 1RJX · PDBe 1RJX · UniProt P00747

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