MolNFT v1 · #20589 · protein
Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein phosphatase 2A activity
1RJG · Carboxy methyl transferase for protein phosphatase 2A…: “Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein phosphatase 2A…”. X-ray diffraction, 1 ligand (SAH), 1 pocket (best druggability…
- PDB
- 1RJG
- Type
- protein
- Length
- 291 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Carboxy methyl transferase for protein phosphatase 2A catalytic subunit
- EC
- 2.1.1.-
- UniProt
- Q04081
- Ligands
- SAH
- Pockets
- 1 · best druggability 0.68
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Carboxy methyl transferase for protein phosphatase 2A catalytic subunit (EC 2.1.1.-) | protein | 291 | 52% helix, 17% strand | Q04081 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 361 | 0.68 | 0.81 | 54 | SAH |
Compared structures
- 1RJG · Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of… · the same entry in another collection · chain A against A, TM-score 1.00
- Q04081 · AlphaFold monomer V2.0 prediction for leucine carboxyl methyltransferase 1 (Q04081) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04081
- Elsewhere: RCSB PDB 1RJG · PDBe 1RJG · UniProt Q04081
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