UniProt Q04081
carboxy methyl transferase for protein phosphatase 2A catalytic subunit (Q04081)
carboxy methyl transferase for protein phosphatase 2A catalytic subunit (UniProt Q04081), EC 2.1.1.-: 12 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 124 pockets. Binding sites, druggability and…
- UniProt
- Q04081
- Protein
- carboxy methyl transferase for protein phosphatase 2A catalytic subunit
- EC
- 2.1.1.-
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 124 · 13 records with a druggable one
Structures
13 records of Q04081 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1RJD | Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein… | x-ray diffraction | A, B, C | SAM, SO4 | 12 (best 0.80) |
| 1RJD | Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein… | x-ray diffraction | A, B, C | SAM, SO4 | 12 (best 0.80) |
| 1RJE | Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein… | x-ray diffraction | A, B, C | SO4, SAH | 15 (best 0.80) |
| 1RJE | Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein… | x-ray diffraction | A, B, C | SO4, SAH | 15 (best 0.80) |
| 1RJF | Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein… | x-ray diffraction | A, B, C | — | 9 (best 0.81) |
| 1RJF | Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein… | x-ray diffraction | A, B, C | — | 9 (best 0.81) |
| 1RJG | Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein… | x-ray diffraction | A | SAH | 1 (best 0.68) |
| 1RJG | Structure of PPM1, a leucine carboxy methyltransferase involved in the regulation of protein… | x-ray diffraction | A | SAH | 1 (best 0.68) |
| 2OB1 | ppm1 with 1,8-ANS | x-ray diffraction | A, B, C | PO4 | 10 (best 0.82) |
| 2OB1 | PPM1 with 1,8-ans | x-ray diffraction | A, B, C | PO4 | 10 (best 0.82) |
| 2OB2 | ppm1 in the absence of 1,8-ANS (cf 1JD) | x-ray diffraction | A, B, C | PO4, SAH | 14 (best 0.82) |
| 2OB2 | PPM1 in the absence of 1,8-ans (cf 1JD) | x-ray diffraction | A, B, C | PO4, SAH | 14 (best 0.82) |
| Q04081 | AlphaFold monomer V2.0 prediction for leucine carboxyl methyltransferase 1 (Q04081) | predicted | A | — | 2 (best 0.78) |
Ligands
Experiment against prediction
- 2OB2 chain A against the predicted model Q04081: TM-score 0.99, RMSD 0.55 Å
- 2OB2 chain A against the predicted model Q04081: TM-score 0.99, RMSD 0.55 Å
- 2OB2 chain C against the predicted model Q04081: TM-score 0.99, RMSD 0.57 Å
- 2OB2 chain C against the predicted model Q04081: TM-score 0.99, RMSD 0.57 Å
- 2OB2 chain B against the predicted model Q04081: TM-score 0.99, RMSD 0.63 Å
- 2OB2 chain B against the predicted model Q04081: TM-score 0.99, RMSD 0.63 Å
- 1RJD chain A against the predicted model Q04081: TM-score 0.99, RMSD 0.51 Å
- 1RJD chain A against the predicted model Q04081: TM-score 0.99, RMSD 0.51 Å
- 2OB1 chain A against the predicted model Q04081: TM-score 0.99, RMSD 0.64 Å
- 2OB1 chain A against the predicted model Q04081: TM-score 0.99, RMSD 0.64 Å
Elsewhere
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