MolNFT v1 · #20582 · protein

Structure of the heterodimer of the conserved GTPase domains of the signal recognition particle (ffh) and its receptor (ftsy)

1RJ9 · Signal recognition protein: “Structure of the heterodimer of the conserved GTPase domains of the signal recognition particle (ffh) and its…”. X-ray diffraction, 2 ligands (GCP, MG), 8 pockets (best druggability 0.83). MolNFT v1…

PDB: 1RJ9
Type: protein
Length: 559 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Signal recognition protein; Signal recognition particle protein
UniProt: P83749, O07347
Ligands: GCP, MG
Pockets: 8 · best druggability 0.83

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Signal recognition protein	protein	277	45% helix, 13% strand	P83749
B	Signal recognition particle protein	protein	282	45% helix, 15% strand	O07347

Ligands and binding sites

GCP · Phosphomethylphosphonic acid guanylate ester · ligand · 2 copies · chains A, B
MG · Magnesium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	475	0.83	0.90	66	MG, GCP
2	99	0.51	0.82	19	empty
3	152	0.44	0.75	21	empty
4	53	0.43	0.83	12	empty
5	95	0.34	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 1560 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

1RJ9 · Structure of the heterodimer of the conserved GTPase domains of the Signal Recognition… · the same entry in another collection · chain A against A, TM-score 1.00
P83749 · AlphaFold monomer V2.0 prediction for signal recognition particle receptor ftsy (P83749) · a predicted model of the same protein · chain A against A, TM-score 0.94
O07347 · AlphaFold monomer V2.0 prediction for signal recognition particle protein (O07347) · a predicted model of the same protein · chain B against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P83749
Every structure of UniProt O07347
Elsewhere: RCSB PDB 1RJ9 · PDBe 1RJ9 · UniProt P83749 · UniProt O07347

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