Crystal structure of resistin-like beta

Structure

x-ray diffraction · 1 distinct chain · 12% helix, 44% strand (DSSP).

Ligands and binding sites

• PT · Platinum (II) ion · metal · 6 copies · chains A, B, C, D, E, F
• P6G · Hexaethylene glycol · additive · 2 copies · chains B, A, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

12 interfaces between chains.

• A–C · 799 Ų buried · 11 hydrogen bonds · protein-protein
• A–B · 793 Ų buried · 15 hydrogen bonds · protein-protein
• B–C · 768 Ų buried · 12 hydrogen bonds · protein-protein
• D–F · 765 Ų buried · 8 hydrogen bonds · protein-protein
• E–F · 740 Ų buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 31 disulfide (disulfide).

Compared structures

• 1RH7 · Crystal Structure of Resistin-like beta · the same entry in another collection · chain C against C, TM-score 1.00
• Q99P86 · AlphaFold monomer V2.0 prediction for resistin-like beta (Q99P86) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q99P86
• Elsewhere: RCSB PDB 1RH7 · PDBe 1RH7 · UniProt Q99P86