MolNFT v1 · #20345 · protein
Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8- tetrahydrofolic acid
1RBZ · Phosphoribosylglycinamide formyltransferase: “Human gar tfase complex structure with polyglutamated 10- (trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8…”. X-ray diffraction, 1 ligand (KT5), 2 pockets (best druggability 0.71). MolNFT…
- PDB
- 1RBZ
- Type
- protein
- Length
- 400 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosylglycinamide formyltransferase
- EC
- 2.1.2.2
- UniProt
- P22102
- Ligands
- KT5
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) | protein | 200 | 36% helix, 24% strand | P22102 |
Ligands and binding sites
- KT5 · N-{4-4-(2,4-diamino-6-oxo-1,6-dihydro-pyrimidin-5-yl)-1-(2,2,2-trifluoro-1,1-dihydroxy-ethyl)-but-2-yl-benzoyl}-gamma-glutamyl-gamma-glutamyl-gamma-glutamyl-gamma-glutamyl-glutamic acid · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 838 | 0.71 | 0.77 | 69 | KT5 |
| 2 | 318 | 0.65 | 0.80 | 39 | KT5 |
Interfaces
1 interface between chains.
- A–B · 297 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22102
- Elsewhere: RCSB PDB 1RBZ · PDBe 1RBZ · UniProt P22102
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