MolNFT v1 · #19866 · protein
Structrue of S127P mutant of cytochrome B5 reductase
1QX4 · NADH-cytochrome B5 reductase: “Structrue of S127P mutant of cytochrome B5 reductase”. X-ray diffraction, 1 ligand (FAD), 5 pockets (best druggability 0.64). MolNFT v1 #19866 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1QX4
- Type
- protein
- Length
- 528 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NADH-cytochrome B5 reductase
- EC
- 1.6.2.2
- UniProt
- P20070
- Ligands
- FAD
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 23% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | NADH-cytochrome B5 reductase (EC 1.6.2.2) | protein | 264 | 23% helix, 38% strand | P20070 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 410 | 0.64 | 0.78 | 48 | FAD |
| 2 | 309 | 0.61 | 0.78 | 39 | FAD |
| 3 | 51 | 0.44 | 0.84 | 16 | empty |
| 4 | 76 | 0.39 | 0.78 | 20 | empty |
| 5 | 67 | 0.32 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 601 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20070
- Elsewhere: RCSB PDB 1QX4 · PDBe 1QX4 · UniProt P20070
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.