MolNFT v1 · #19767 · protein
Crystal structure of the fifth laminin G-like module of the mouse laminin ALPHA2 chain
1QU0: “Crystal structure of the fifth laminin G-like module of the mouse laminin ALPHA2 chain”. X-ray diffraction, 2 ligands (CA, SO4), 5 pockets (best druggability 0.53). MolNFT v1 #19767 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1QU0
- Type
- protein
- Length
- 726 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Laminin ALPHA2 chain
- UniProt
- Q60675
- Ligands
- CA, SO4
- Pockets
- 5 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | Laminin ALPHA2 chain | protein | 181 | 3% helix, 51% strand | Q60675 |
| C | Laminin ALPHA2 chain | protein | 183 | 3% helix, 51% strand | Q60675 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A, B, C, D
- SO4 · Sulfate ion · ion · 7 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 213 | 0.53 | 0.78 | 49 | empty |
| 2 | 219 | 0.49 | 0.75 | 37 | empty |
| 3 | 221 | 0.47 | 0.74 | 35 | empty |
| 4 | 217 | 0.47 | 0.74 | 36 | empty |
| 5 | 192 | 0.45 | 0.74 | 30 | CA, SO4 |
Interfaces
4 interfaces between chains.
- A–B · 699 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 694 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 258 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 116 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1QU0 · Crystal structure of the fifth laminin G-like module of the mouse laminin ALPHA2 chain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q60675
- Elsewhere: RCSB PDB 1QU0 · PDBe 1QU0 · UniProt Q60675
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