MolNFT v1 · #19563 · protein

NMR structure of the 0.5B anti-HIV antibody complex with the GP120 V3 peptide

1QNZ · 0.5B antibody (heavy chain): “NMR structure of the 0.5B anti-HIV antibody complex with the GP120 V3 peptide”. Solution nmr. MolNFT v1 #19563 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1QNZ
Type: protein
Length: 249 residues
Chains: 3
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 0.5B antibody (heavy chain); 0.5B antibody (light chain); GP120
UniProt: P01665, Q79416

Structure

solution nmr · 3 distinct chains · 2% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
H	0.5B antibody (heavy chain)	protein	119	3% helix, 51% strand	—
L	0.5B antibody (light chain)	protein	112	3% helix, 46% strand	P01665
P	GP120	protein	18	0% helix, 33% strand	Q79416

Interfaces

3 interfaces between chains.

H–L · 846 Å² buried · 11 hydrogen bonds · protein-protein
H–P · 582 Å² buried · 22 hydrogen bonds · protein-protein
L–P · 192 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1QNZ · NMR structure of the 0.5b anti-HIV antibody complex with the gp120 V3 peptide · the same entry in another collection · chain H against H, TM-score 1.00
P01665 · AlphaFold monomer V2.0 prediction for ig kappa chain V-III region pc 7043 (P01665) · a predicted model of the same protein · chain L against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01665
Every structure of UniProt Q79416
Elsewhere: RCSB PDB 1QNZ · PDBe 1QNZ · UniProt P01665 · UniProt Q79416

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