MolNFT v1 · #1953 · protein

Free P56LCK SH2 domain

1BHH · T-lymphocyte-specific protein tyrosine kinase P56LCK: “Free P56LCK SH2 domain”. X-ray diffraction, 1 pocket (best druggability 0.36). MolNFT v1 #1953 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1BHH
Type: protein
Length: 207 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-lymphocyte-specific protein tyrosine kinase P56LCK; P56 lck tyrosine kinase SH2 domain
EC: 2.7.1.112
UniProt: P06239
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	T-lymphocyte-specific protein tyrosine kinase P56LCK (EC 2.7.1.112)	protein	104	18% helix, 35% strand	P06239
B	P56 lck tyrosine kinase SH2 domain	protein	103	17% helix, 29% strand	P06239

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	82	0.36	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 462 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

1BHH · Free P56LCK SH2 domain · the same entry in another collection · chain A against A, TM-score 1.00
P06239 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase lck (P06239) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06239
Elsewhere: RCSB PDB 1BHH · PDBe 1BHH · UniProt P06239

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