MolNFT v1 · #19392 · protein
Human insulin hexamers with chain B his mutated to tyr
1QJ0 · Insulin a chain: “Human insulin hexamers with chain B his mutated to tyr”. X-ray diffraction, 2 ligands (ZN, CL). MolNFT v1 #19392 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1QJ0
- Type
- protein
- Length
- 100 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin a chain; Insulin B chain
- UniProt
- P01308
- Ligands
- ZN, CL
Structure
x-ray diffraction · 3 distinct chains · 57% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin a chain | protein | 21 | 52% helix, 5% strand | P01308 |
| B | Insulin B chain | protein | 28 | 68% helix, 11% strand | P01308 |
| D | Insulin B chain | protein | 30 | 50% helix, 10% strand | P01308 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
5 interfaces between chains.
- C–D · 800 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 644 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 633 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 61 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 31 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1QJ0 · Human insulin hexamers with chain B his mutated to tyr · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 1QJ0 · PDBe 1QJ0 · UniProt P01308
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