MolNFT v1 · #19368 · protein
Crystal structure of stromelysin catalytic domain
1QIC · Protein (stromelysin-1): “Crystal structure of stromelysin catalytic domain”. X-ray diffraction, 2 ligands (CA, ZN), 5 pockets (best druggability 0.59). MolNFT v1 #19368 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1QIC
- Type
- protein
- Length
- 644 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (stromelysin-1)
- EC
- 3.4.24.17
- UniProt
- P08254
- Ligands
- CA, ZN
- Pockets
- 5 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Protein (stromelysin-1) (EC 3.4.24.17) | protein | 161 | 27% helix, 17% strand | P08254 |
Ligands and binding sites
- CA · Calcium ion · metal · 12 copies · chains A, B, C, D
- ZN · Zinc ion · metal · 8 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 172 | 0.59 | 0.82 | 35 | ZN |
| 2 | 248 | 0.58 | 0.79 | 38 | ZN |
| 3 | 159 | 0.57 | 0.82 | 29 | ZN |
| 4 | 169 | 0.56 | 0.80 | 37 | ZN |
| 5 | 213 | 0.52 | 0.77 | 33 | empty |
Interfaces
2 interfaces between chains.
- B–D · 307 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 43 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08254
- Elsewhere: RCSB PDB 1QIC · PDBe 1QIC · UniProt P08254
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.