MolNFT v1 · #19245 · protein
Human class I histocompatibility antigen (HLA-a 0201) complex with a nonameric peptide from melanoma-associated antigen 3 (residues 271- 279)
1QEW · Protein (HLA class I histocompatibility antigen, B-35 B*…: “Human class I histocompatibility antigen (HLA-a 0201) complex with a nonameric peptide from…”. X-ray diffraction, 3 pockets (best druggability 0.70). MolNFT v1 #19245 on…
- PDB
- 1QEW
- Type
- protein
- Length
- 384 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (HLA class I histocompatibility antigen, B-35 B* 3501 alpha chain); Protein…
- UniProt
- P01892, P01884, P43357
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (HLA class I histocompatibility antigen, B-35 B* 3501 alpha chain) | protein | 275 | 27% helix, 39% strand | P01892 |
| B | Protein (beta-2-microglobulin) | protein | 100 | 0% helix, 49% strand | P01884 |
| C | Protein (melanoma-associated antigen 3) | protein | 9 | 0% helix, 0% strand | P43357 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 635 | 0.70 | 0.78 | 55 | empty |
| 2 | 78 | 0.43 | 0.81 | 23 | empty |
| 3 | 105 | 0.42 | 0.77 | 19 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1367 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 842 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1QEW · Human class I histocompatibility antigen (HLA-a 0201) complex with a nonameric peptide… · the same entry in another collection · chain A against A, TM-score 1.00
- P43357 · AlphaFold monomer V2.0 prediction for melanoma-associated antigen 3 (P43357) · a predicted model of the same protein · chain C against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01892
- Every structure of UniProt P01884
- Every structure of UniProt P43357
- Elsewhere: RCSB PDB 1QEW · PDBe 1QEW · UniProt P01892 · UniProt P01884 · UniProt P43357
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