MolNFT v1 · #19235 · protein
N-terminal domain, voltage-gated potassium channel KV1.2 residues 33-131
1QDV · KV1.2 voltage-gated potassium channel: “N-terminal domain, voltage-gated potassium channel KV1.2 residues 33-131”. X-ray diffraction, 1 pocket (best druggability 0.84). MolNFT v1 #19235 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1QDV
- Type
- protein
- Length
- 396 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- KV1.2 voltage-gated potassium channel
- UniProt
- P63142
- Pockets
- 1 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | KV1.2 voltage-gated potassium channel | protein | 99 | 44% helix, 18% strand | P63142 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1072 | 0.84 | 0.85 | 92 | empty |
Interfaces
5 interfaces between chains.
- A–D · 771 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 700 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 689 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 665 Ų buried · 22 hydrogen bonds · protein-protein
- A–C · 43 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1QDV · N-terminal domain, voltage-gated potassium channel KV1.2 residues 33-131 · the same entry in another collection · chain A against A, TM-score 1.00
- P63142 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily a member… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63142
- Elsewhere: RCSB PDB 1QDV · PDBe 1QDV · UniProt P63142
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