MolNFT v1 · #19139 · protein
Unexpected modes of PDZ domain scaffolding revealed by structure of nnos-syntrophin complex
1QAV · Alpha-1 syntrophin (residues 77-171): “Unexpected modes of PDZ domain scaffolding revealed by structure of nnos-syntrophin complex”. X-ray diffraction, 2 pockets (best druggability 0.45). MolNFT v1 #19139 on GenesisL1: 3D structure…
- PDB
- 1QAV
- Type
- protein
- Length
- 205 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-1 syntrophin (residues 77-171); Neuronal nitric oxide synthase (residues 1-130)
- UniProt
- Q61234, P29476
- Pockets
- 2 · best druggability 0.45
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Alpha-1 syntrophin (residues 77-171) | protein | 90 | 18% helix, 40% strand | Q61234 |
| B | Neuronal nitric oxide synthase (residues 1-130) | protein | 115 | 12% helix, 46% strand | P29476 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 139 | 0.45 | 0.77 | 23 | empty |
| 2 | 70 | 0.39 | 0.79 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 808 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1QAV · Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of NNOS-Syntrophin… · the same entry in another collection · chain A against A, TM-score 1.00
- Q61234 · AlphaFold monomer V2.0 prediction for alpha-1-syntrophin (Q61234) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q61234
- Every structure of UniProt P29476
- Elsewhere: RCSB PDB 1QAV · PDBe 1QAV · UniProt Q61234 · UniProt P29476
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