MolNFT v1 · #191330 · protein
Structure of the mycobacterium tuberculosis 20S proteasome bound to the C-terminal gqyl motif of the ADP-bound mpa ATPase
8D6W · Proteasome subunit alpha: “Structure of the mycobacterium tuberculosis 20S proteasome bound to the C-terminal gqyl motif of the…”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #191330 on GenesisL1: 3D…
- PDB
- 8D6W
- Type
- protein
- Length
- 6,146 residues
- Chains
- 35
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Proteasome subunit alpha; Proteasome subunit beta; Proteasome-associated ATPase
- EC
- 3.4.25.1
- UniProt
- A5U4D5, A0A045HFG5, A1KKF8
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 3 distinct chains · 41% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, D, E, F, G, H, I, J, K, L, M, N, O | Proteasome subunit alpha (EC 3.4.25.1) | protein | 215 | 42% helix, 24% strand | A5U4D5 |
| P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c | Proteasome subunit beta (EC 3.4.25.1) | protein | 222 | 41% helix, 30% strand | A0A045HFG5 |
| d, e, f, g, h, i, j | Proteasome-associated ATPase | protein | 4 | 0% helix, 0% strand | A1KKF8 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 548 | 0.84 | 0.90 | 45 | empty |
| 2 | 555 | 0.84 | 0.89 | 47 | empty |
| 3 | 559 | 0.84 | 0.89 | 46 | empty |
| 4 | 549 | 0.84 | 0.89 | 46 | empty |
| 5 | 553 | 0.83 | 0.89 | 44 | empty |
Interfaces
84 interfaces between chains.
- K–L · 787 Ų buried · 2 hydrogen bonds · protein-protein
- S–Z · 785 Ų buried · 17 hydrogen bonds · protein-protein
- R–a · 778 Ų buried · 17 hydrogen bonds · protein-protein
- Q–b · 776 Ų buried · 18 hydrogen bonds · protein-protein
- V–W · 773 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 8D6W · Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5U4D5
- Every structure of UniProt A0A045HFG5
- Every structure of UniProt A1KKF8
- Elsewhere: RCSB PDB 8D6W · PDBe 8D6W · UniProt A5U4D5 · UniProt A0A045HFG5 · UniProt A1KKF8
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