UniProt A5U4D5
Proteasome subunit alpha (A5U4D5)
Proteasome subunit alpha (UniProt A5U4D5), EC 3.4.25.1: 22 experimental structures and 1 predicted model on GenesisL1, 100 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A5U4D5
- Protein
- Proteasome subunit alpha
- EC
- 3.4.25.1
- Experimental structures
- 22
- Predicted models
- 1
- Pockets
- 100 · 8 records with a druggable one
Structures
23 records of A5U4D5 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5THO | Crystal Structure of Mycobacterium Tuberculosis Proteasome in complex with N,C-capped Dipeptide… | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | 13 (best 0.80) |
| 5THO | Crystal structure of mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide… | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 5TRG | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide DPLG-2 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 5TRG | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide dplg-2 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 5TRR | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2169 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 5TRR | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide PKS2169 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 5TRS | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2144 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | 14 (best 0.85) |
| 5TRS | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide PKS2144 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 5TRY | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide PKS2206 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 5TS0 | Structure of Mycobacterium tuberculosis proteasome in complex with N,C-capped dipeptide PKS2208 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | 13 (best 0.80) |
| 5TS0 | Structure of mycobacterium tuberculosis proteasome in complex with N, C-capped dipeptide PKS2208 | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 6BGL | Doubly PafE-capped 20S core particle in Mycobacterium tuberculosis | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | 13 (best 0.76) |
| 6BGL | Doubly pafe-capped 20S core particle in mycobacterium tuberculosis | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 6BGO | Singly PafE-capped 20S CP in Mycobacterium tuberculosis | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 6BGO | Singly pafe-capped 20S cp in mycobacterium tuberculosis | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 6WNK | Macrocyclic peptides TDI5575 that selectively inhibit the mycobacterium tuberculosis proteasome | x-ray diffraction | A, B, C, D, E, F, G, O, P, Q, R, S, T, U | — | — |
| 8D6V | Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of… | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | 13 (best 0.79) |
| 8D6V | Structure of the mycobacterium tuberculosis 20S proteasome bound to the C-terminal gqyl motif of… | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 8D6W | Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of… | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | 13 (best 0.79) |
| 8D6W | Structure of the mycobacterium tuberculosis 20S proteasome bound to the C-terminal gqyl motif of… | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O | — | — |
| 8D6X | Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ATP-bound Mpa ATPase | electron microscopy | k, l, m, n, o, G, H, I, J, K, L, M, N, O | — | 7 (best 0.83) |
| 8D6Y | Structure of the Mycobacterium tuberculosis 20S proteasome bound to the ADP-bound Mpa ATPase | electron microscopy | k, l, m, n, o, G, H, I, J, K, L, M, N, O | — | 10 (best 0.79) |
| A5U4D5 | AlphaFold monomer V2.0 prediction for proteasome subunit alpha (A5U4D5) | predicted | A | — | 4 (best 0.37) |
Experiment against prediction
- 8D6W chain L against the predicted model A5U4D5: TM-score 0.99, RMSD 0.48 Å
- 8D6W chain O against the predicted model A5U4D5: TM-score 0.99, RMSD 0.48 Å
- 8D6W chain N against the predicted model A5U4D5: TM-score 0.99, RMSD 0.48 Å
- 8D6W chain J against the predicted model A5U4D5: TM-score 0.99, RMSD 0.48 Å
- 8D6W chain K against the predicted model A5U4D5: TM-score 0.99, RMSD 0.49 Å
- 8D6W chain A against the predicted model A5U4D5: TM-score 0.99, RMSD 0.49 Å
- 8D6W chain M against the predicted model A5U4D5: TM-score 0.99, RMSD 0.49 Å
- 8D6V chain O against the predicted model A5U4D5: TM-score 0.99, RMSD 0.51 Å
- 8D6V chain K against the predicted model A5U4D5: TM-score 0.99, RMSD 0.52 Å
- 5TRG chain P against the predicted model A5U4D5: TM-score 0.99, RMSD 0.52 Å
Elsewhere
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