MolNFT v1 · #191309 · protein

Crystal structure of human STAT1 in complex with the repeat region from toxoplasma protein tgist

8D3F · Signal transducer and activator of transcription 1…: “Crystal structure of human STAT1 in complex with the repeat region from toxoplasma protein tgist”. X-ray diffraction, 2 pockets (best druggability 0.51). MolNFT v1 #191309 on…

PDB: 8D3F
Type: protein
Length: 572 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Signal transducer and activator of transcription 1- ALPHA/BETA,INHIBITOR of…
UniProt: P42224, A0A7J6KA90
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 46% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Signal transducer and activator of transcription 1- ALPHA/BETA,INHIBITOR of STAT1-dependent transcription tgist	protein	572	46% helix, 18% strand	P42224, A0A7J6KA90

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	173	0.51	0.78	25	empty
2	232	0.49	0.74	37	empty

Compared structures

8D3F · Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma… · the same entry in another collection · chain A against A, TM-score 1.00
P42224 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42224
Every structure of UniProt A0A7J6KA90
Elsewhere: RCSB PDB 8D3F · PDBe 8D3F · UniProt P42224 · UniProt A0A7J6KA90

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