Research workbench
Crystal structure of human STAT1 in complex with the repeat region from toxoplasma protein tgist
Analyse Crystal structure of human STAT1 in complex with the repeat region from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 8D3F
- Type
- protein
- Length
- 572 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Signal transducer and activator of transcription 1- ALPHA/BETA,INHIBITOR of…
- UniProt
- P42224, A0A7J6KA90
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Signal transducer and activator of transcription 1- ALPHA/BETA,INHIBITOR of STAT1-dependent transcription tgist | protein | 572 | 46% helix, 18% strand | P42224, A0A7J6KA90 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 173 | 0.51 | 0.78 | 25 | empty |
| 2 | 232 | 0.49 | 0.74 | 37 | empty |
Compared structures
- 8D3F · Crystal structure of human STAT1 in complex with the repeat region from Toxoplasma… · the same entry in another collection · chain A against A, TM-score 1.00
- P42224 · AlphaFold monomer V2.0 prediction for signal transducer and activator of transcription… · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42224
- Every structure of UniProt A0A7J6KA90
- Elsewhere: RCSB PDB 8D3F · PDBe 8D3F · UniProt P42224 · UniProt A0A7J6KA90
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