MolNFT v1 · #191165 · protein
Structure of human REP15 in complex with bovine RAB3C.
8A4A · RAB15 effector protein: “Structure of human REP15 in complex with bovine RAB3C.”. X-ray diffraction, 2 ligands (GNP, MG), 6 pockets (best druggability 0.62). MolNFT v1 #191165 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 8A4A
- Type
- protein
- Length
- 379 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RAB15 effector protein; RAS-related protein rab-3C
- UniProt
- Q6BDI9, P10949
- Ligands
- GNP, MG
- Pockets
- 6 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RAB15 effector protein | protein | 207 | 43% helix, 22% strand | Q6BDI9 |
| B | RAS-related protein rab-3C | protein | 172 | 37% helix, 28% strand | P10949 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains B
- MG · Magnesium ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 363 | 0.62 | 0.78 | 45 | GNP, MG |
| 2 | 60 | 0.39 | 0.79 | 11 | empty |
| 3 | 53 | 0.38 | 0.80 | 14 | empty |
| 4 | 58 | 0.36 | 0.79 | 15 | empty |
| 5 | 60 | 0.31 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 881 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 8A4A · Structure of human Rep15 in complex with bovine Rab3C. · the same entry in another collection · chain A against A, TM-score 1.00
- P10949 · AlphaFold monomer V2.0 prediction for RAS-related protein rab-3C (P10949) · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q6BDI9 · AlphaFold monomer V2.0 prediction for RAB15 effector protein (Q6BDI9) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6BDI9
- Every structure of UniProt P10949
- Elsewhere: RCSB PDB 8A4A · PDBe 8A4A · UniProt Q6BDI9 · UniProt P10949
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.