Engineered protein targeting the zika viral envelope fusion loop

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 31% strand (DSSP).

Ligands and binding sites

• EDO · 1,2-ethanediol · additive · 17 copies · chains A, B
• ACY · Acetic acid · additive · 3 copies · chains A, B
• PGE · Triethylene glycol · additive · 2 copies · chains A, B
• SIN · Succinic acid · additive · 2 copies · chains A, B
• P6G · Hexaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 842 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

• 7ZFM · Engineered Protein Targeting the Zika Viral Envelope Fusion Loop · the same entry in another collection · chain A against A, TM-score 1.00
• P0AFL3 · AlphaFold monomer V2.0 prediction for peptidyl-prolyl cis-trans isomerase a (P0AFL3) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P0AFL3
• Elsewhere: RCSB PDB 7ZFM · PDBe 7ZFM · UniProt P0AFL3