MolNFT v1 · #191009 · protein
RNA binding induces an allosteric switch in CYP33 to repress MLL1 mediated transcription
7ZEY · Peptidyl-prolyl cis-trans isomerase E: “RNA binding induces an allosteric switch in CYP33 to repress MLL1 mediated transcription”. Solution nmr, 1 ligand (ZN), 1 pocket (best druggability 0.31). MolNFT v1 #191009 on GenesisL1: 3D…
- PDB
- 7ZEY
- Type
- protein
- Length
- 181 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidyl-prolyl cis-trans isomerase E; Mll cleavage product N320
- EC
- 5.2.1.8
- UniProt
- Q9UNP9, Q03164
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.31
Structure
solution nmr · 2 distinct chains · 26% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidyl-prolyl cis-trans isomerase E (EC 5.2.1.8) | protein | 117 | 29% helix, 21% strand | Q9UNP9 |
| B | Mll cleavage product N320 | protein | 64 | 20% helix, 13% strand | Q03164 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.31 | 0.75 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1251 Ų buried · 20 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UNP9
- Every structure of UniProt Q03164
- Elsewhere: RCSB PDB 7ZEY · PDBe 7ZEY · UniProt Q9UNP9 · UniProt Q03164
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