MolNFT v1 · #190939 · protein
Cytoplasmic dynein-1 motor domain
7Z8G · Cytoplasmic dynein 1 heavy chain 1: “Cytoplasmic dynein-1 motor domain”. Electron microscopy, 4 ligands (ANP, ADP, ATP), 20 pockets (best druggability 0.83). MolNFT v1 #190939 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7Z8G
- Type
- protein
- Length
- 3,047 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytoplasmic dynein 1 heavy chain 1
- UniProt
- Q14204
- Ligands
- ANP, ADP, ATP, MG
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 55% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytoplasmic dynein 1 heavy chain 1 | protein | 3047 | 55% helix, 10% strand | Q14204 |
Ligands and binding sites
- ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 2 copies · chains A
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1090 | 0.83 | 0.84 | 120 | ANP |
| 2 | 1072 | 0.82 | 0.83 | 101 | ANP |
| 3 | 966 | 0.81 | 0.82 | 86 | empty |
| 4 | 105 | 0.78 | 0.98 | 19 | empty |
| 5 | 870 | 0.76 | 0.80 | 66 | ATP |
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14204
- Elsewhere: RCSB PDB 7Z8G · PDBe 7Z8G · UniProt Q14204
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