MolNFT v1 · #190651 · protein + DNA

Crystal structure of the dimeric BRN2 (POU3F2) pou domain bound to palindromic more DNA

7XRC · Pou domain protein: “Crystal structure of the dimeric BRN2 (POU3F2) pou domain bound to palindromic more DNA”. X-ray diffraction, 1 pocket (best druggability 0.68). MolNFT v1 #190651 on GenesisL1: 3D structure, binding sites and…

PDB: 7XRC
Type: protein + DNA
Length: 155 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pou domain protein; More palindromic oct factor recognition element (more)
UniProt: A0A6I8N999
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Pou domain protein	protein	134	70% helix, 0% strand	A0A6I8N999
A	More palindromic oct factor recognition element (more)	dna	11	—	—
B	More palindromic oct factor recognition element (more)	dna	10	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.68	0.91	27	empty

Interfaces

3 interfaces between chains.

C–B · 732 Å² buried · 17 hydrogen bonds · protein-nucleic
C–A · 521 Å² buried · 12 hydrogen bonds · protein-nucleic
A–B · 466 Å² buried · 41 hydrogen bonds · nucleic-nucleic

Compared structures

7XRC · Crystal Structure of the dimeric Brn2 (Pou3f2) POU domain bound to palindromic MORE DNA · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A6I8N999
Elsewhere: RCSB PDB 7XRC · PDBe 7XRC · UniProt A0A6I8N999

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