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Crystal structure of the dimeric BRN2 (POU3F2) pou domain bound to palindromic more DNA

Analyse Crystal structure of the dimeric BRN2 (POU3F2) pou domain bound to palindromic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7XRC
Type: protein + DNA
Length: 155 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pou domain protein; More palindromic oct factor recognition element (more)
UniProt: A0A6I8N999
Pockets: 1 · best druggability 0.68

Structure

x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Pou domain protein	protein	134	70% helix, 0% strand	A0A6I8N999
A	More palindromic oct factor recognition element (more)	dna	11	—	—
B	More palindromic oct factor recognition element (more)	dna	10	—	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.68	0.91	27	empty

Interfaces

3 interfaces between chains.

C–B · 732 Å² buried · 17 hydrogen bonds · protein-nucleic
C–A · 521 Å² buried · 12 hydrogen bonds · protein-nucleic
A–B · 466 Å² buried · 41 hydrogen bonds · nucleic-nucleic

Compared structures

7XRC · Crystal Structure of the dimeric Brn2 (Pou3f2) POU domain bound to palindromic MORE DNA · the same entry in another collection · chain C against C, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A6I8N999
Elsewhere: RCSB PDB 7XRC · PDBe 7XRC · UniProt A0A6I8N999

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