MolNFT v1 · #190585 · protein
Crystal structure of human mmp-2 catalytic domain in complex with inhibitor
7XJO: “Crystal structure of human mmp-2 catalytic domain in complex with inhibitor”. X-ray diffraction, 6 ligands (OUL, LEA, H7I). MolNFT v1 #190585 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7XJO
- Type
- protein
- Length
- 339 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Ligands
- OUL, LEA, H7I, CA, ZN, CL
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 166 | — | — |
| B | — | protein | 165 | — | — |
| C, D | — | protein | 4 | — | — |
Ligands and binding sites
- OUL · 4-(4-aminocarbonylphenoxy)benzamide · ligand · 2 copies · chains A, C, B, D
- LEA · Pentanoic acid · ligand · 2 copies · chains A, C, B, D
- H7I · (4~{S})-5-[(2~{S})-2-(2-azanyl-2-oxidanylidene-ethyl) pyrrolidin-1-yl]-4-(methylamino)-5-oxidanylidene-pentanoic acid · ligand · 2 copies · chains A, C, B, D
- CA · Calcium ion · metal · 7 copies · chains A, B
- ZN · Zinc ion · metal · 4 copies · chains A, C, B, D
- CL · Chloride ion · ion · 3 copies · chains A, B
- B3P · 2-[3-(2-hydroxy-1,1-dihydroxymethyl-ethylamino)-propylamino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7XJO · Crystal structure of human MMP-2 catalytic domain in complex with inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7XJO · PDBe 7XJO
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