MolNFT v1 · #190368 · protein

Gpr domain closed form of drosophila P5CS filament with glutamate, ATP, and NADPH

7WXG · Delta-1-pyrroline-5-carboxylate synthase: “Gpr domain closed form of drosophila P5CS filament with glutamate, ATP, and NADPH”. Electron microscopy, 1 ligand (NAP), 5 pockets (best druggability 0.65). MolNFT v1 #190368 on GenesisL1…

PDB: 7WXG
Type: protein
Length: 430 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Delta-1-pyrroline-5-carboxylate synthase
EC: 2.7.2.11, 1.2.1.41
UniProt: Q9VNW6
Ligands: NAP
Pockets: 5 · best druggability 0.65

Structure

electron microscopy · 1 distinct chain · 42% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Delta-1-pyrroline-5-carboxylate synthase (EC 2.7.2.11, 1.2.1.41)	protein	430	42% helix, 14% strand	Q9VNW6

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	95	0.65	0.90	26	empty
2	255	0.52	0.76	44	NAP
3	71	0.32	0.75	19	empty
4	61	0.30	0.75	17	empty
5	66	0.30	0.74	16	empty

Compared structures

7WXG · GPR domain closed form of Drosophila P5CS filament with glutamate, ATP, and NADPH · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VNW6
Elsewhere: RCSB PDB 7WXG · PDBe 7WXG · UniProt Q9VNW6

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