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Gpr domain closed form of drosophila P5CS filament with glutamate, ATP, and NADPH

Analyse Gpr domain closed form of drosophila P5CS filament with glutamate, ATP, and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7WXG
Type: protein
Length: 430 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Delta-1-pyrroline-5-carboxylate synthase
EC: 2.7.2.11, 1.2.1.41
UniProt: Q9VNW6
Ligands: NAP
Pockets: 5 · best druggability 0.65

Structure

electron microscopy · 1 distinct chain · 42% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Delta-1-pyrroline-5-carboxylate synthase (EC 2.7.2.11, 1.2.1.41)	protein	430	42% helix, 14% strand	Q9VNW6

Ligands and binding sites

NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	95	0.65	0.90	26	empty
2	255	0.52	0.76	44	NAP
3	71	0.32	0.75	19	empty
4	61	0.30	0.75	17	empty
5	66	0.30	0.74	16	empty

Compared structures

7WXG · GPR domain closed form of Drosophila P5CS filament with glutamate, ATP, and NADPH · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9VNW6
Elsewhere: RCSB PDB 7WXG · PDBe 7WXG · UniProt Q9VNW6

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