MolNFT v1 · #190350 · protein
Choline transporter-like protein 1
7WWB: “Choline transporter-like protein 1”. Electron microscopy, 2 ligands (CHT, CLR), 12 pockets (best druggability 0.57). MolNFT v1 #190350 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7WWB
- Type
- protein
- Length
- 666 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Choline transporter-like protein 1
- UniProt
- Q8WWI5
- Ligands
- CHT, CLR
- Pockets
- 12 · best druggability 0.57
Structure
electron microscopy · 1 distinct chain · 77% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Choline transporter-like protein 1 | protein | 333 | 77% helix, 1% strand | Q8WWI5 |
Ligands and binding sites
- CHT · Choline ion · ligand · 2 copies · chains A, B
- CLR · Cholesterol · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 341 | 0.57 | 0.76 | 34 | CHT |
| 2 | 283 | 0.55 | 0.76 | 30 | CHT |
| 3 | 91 | 0.55 | 0.85 | 19 | empty |
| 4 | 119 | 0.53 | 0.82 | 20 | empty |
| 5 | 226 | 0.51 | 0.75 | 28 | CLR |
Interfaces
1 interface between chains.
- A–B · 252 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WWI5
- Elsewhere: RCSB PDB 7WWB · PDBe 7WWB · UniProt Q8WWI5
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